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Introduction

Emerging and reemerging viruses pose a great threat to the entire world. Besides the COVID-19 pandemic, previous viruses such as SARS-CoV-1, avian and newly drifted human influenza viruses, enterovirus, and zika viruses have severely threatened human health and have a huge socioeconomic, transportation, ecological, and education impact. Mankind must face the resurgence of these viruses and may even face attacks by other novel viruses. Since the Research Center for Emerging Viral Infections (RCEVI) at Chang Gung University was founded in 2009, it has studied these mutation-prone RNA viruses for a long period of time (causes of emerging and reemerging infections). The results of talent development contributed greatly in the once-in-100-years COVID-19 pandemic, including rapid virus identification, isolation of virus strains, gene database construction for follow-up on infection sources, and vaccine and antiviral research and developments. We hope to operate this research center in a sustainable manner and continue talent development through the collaboration of experts from different fields to complete the following missions:
(1) Identification of emerging viral infections: Combining the latest biotechnology and artificial intelligence to develop novel diagnostic reagents for clinical use.
(2) Research on emerging viruses: Understanding the pathogenesis of emerging viruses at a molecular level and cellular level, animal models to human trials, combining molecular virology, immunology, information science, biomedical engineering, and clinical medicine, and developing methods to relieve and treat emerging infections.
(3) Establishing a bridge between basic science and clinical science: Our center has established a good collaborative model with Chang Gung Hospital since the enterovirus 71 epidemic in Taiwan in 1998 and collaboration was further strengthened in the COVID-19 pandemic. In the future, potential antiviral drugs or treatments will be pushed for clinical application. Clinical phenomena are also understood through basic research, allowing us to help patients.
(4) Solid international collaboration is used to promote research on emerging viral infections: Currently, the center has joined the International Centers for Research in Emerging Infectious Diseases (CREID) Network and we will continue to exchange researchers and develop local and overseas talents. For example, in this COVID-19 pandemic, efficient collaboration was established within the shortest possible time to jointly combat the pandemic.
新興與再興病毒對整個世界的威脅極大,除了COVID-19全球大流行的震撼之外,之前SARS-CoV-1、禽流感、腸病毒、新型豬流感等病毒嚴重危害到人類的生命,對社會經濟、交通、生態及教育層面也均造成很大的衝擊。人類必須面對這些病毒的捲土重來,也可能會再遭遇嶄新的病毒攻擊。長庚大學新興病毒研究中心自2009年成立以來,長期研究這類易突變的RNA病毒(會導致新興與再興的感染症)。人才培育的結果在此次百年大疫COVID-19發揮了很大的貢獻,包括病毒快速鑑定、病毒株分離、基因資料庫建立以追蹤感染源,疫苗抗病毒研發等。我們期許永續經營此研究中心,通過不同領域的專家共同合作,繼續培育人才,完成以下使命:
(1)辨識新興病毒感染疾病:結合最新生物技術及人工智慧開發新穎檢驗試劑於臨床使用。
(2)進行新興病毒跨領域之研究:從分子層次、細胞層次、動物模式到人體試驗,結合分子病毒學、免疫學、資訊學、生醫工程及臨床醫學等共同對新興病毒的致病毒機轉有所了解,而研發減緩及治療新興感染症的方法。
(3)建立基礎科學及臨床科學的橋樑:本中心與長庚醫院自1998年台灣地區爆發腸病毒71型大流行時,已形成良好的合作模式,此次COVID-19疫情更加強合作的面向。此後將持續將有潛力的抗病毒藥物或治療方式推向臨床應用。臨床的現象,也會透過基礎科學研究而獲得解答,進而幫助病人。
(4)藉由紮實的國際合作以促進新興病毒感染症之研究:目前中心加入全球感染症網的研究(CREID),會持續交換研究人員,培育國內外人才,如同此次COVID-19病情一般,可以在最短時間內建立最有效率的合作,共同對抗疫情。

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