Dr. Avijit Dutta

Email:               duttijiva@gmail.com
TEL：

Office:                +886-3-2118800 ext 

Personal:          +886-987854626

Fax：                 +886-3-2118700

Dr. Avijit Dutta obtained his bachelor’s and master’s degrees in Zoology from Vidyasagar University and Ph.D. in Science from Jadavpur University, India. He then moved to Taiwan in 2007. With Prof. Ching-Tai Huang of Chang Gung Memorial Hospital, he established an influenza study platform to study antigen-specific T cell immunity to influenza virus infection. Through the use of this ‘Influenza hemagglutinin (HA)-specific transgenic mouse model system’, his team is studying the activation and regulation of the activation of antigen-specific T cell response to influenza virus infection in vivo. His team is also screening plant-derived natural compounds for their potential anti-influenza activity.

In addition, Dr. Dutta is working on the novel markers and mechanisms of regulatory T cells in non-infectious settings. Novel markers are of special interest as they are probable immune checkpoints with the potential of clinical application in cancer immunotherapy.

Research Interests: Immunology

  1. Infectious diseases
    • Severe influenza-
      • Control of cytokine storm: Antigen-specific immunity: cytokines & defined T cell subsets
      • Vaccine research: Delivery optimization

    • Severe influenza with bacterial super-infection-
      • Disease amelioration with balanced immunity: Interactions among bacteria, Virus and host immunity

  1. Cancer & tumor-
    • Reversal of immune checkpoints:
    • Regulatory T cells:
      • Identification of novel markers, Decoding regulatory landscapes & antibody-mediated reversal of immune checkpoints

  1. Immune modulation with natural plant products-
    • Biological activity
    • Target identification
    • Mechanism/s of action

Professional membership:

Member, The American Association of Immunologists

Member, Chinese Immunological Society (Taiwan)

Reviewer, Phytomedicine

Reviewer, Journal of Immunology Research

Education:

Ph.D.: Science, Jadavpur University, India, 2006.

M.Sc.: Zoology, Vidyasagar University, India, 1998.

B.Sc.: Zoology (Honours), Midnapur College, Vidyasagar University, India, 1996.

Professional Affiliations:

October 2020 ~ , Assistant Research Fellow, Research center For Emerging Viral Infections, Chang Gung University, Taiwan.

August 2016 ~ , Assistant Research Scholar, Division of Infectious Diseases, Department of Medicine, Chang Gung Memorial Hospital, Taiwan.

March 2007 ~ July 2016, Postdoctoral Research Fellow, Division of Infectious Diseases, Department of Medicine, Chang Gung Memorial Hospital, Taiwan.

December 2006 ~ February 2007, Post-PhD Senior Research Fellow, Department of Pharmacology, Institute of Postgraduate Medical Education & Research, Kolkata, India.

November 2006, Visiting Research Fellow, Institut für Molekulare Infektionsbiologie, Julias-Maximilians Universitat Wurzburg, Germany.

September 2002 ~ October 2006, PhD Student, Jadavpur University, India (Institute 1: Division of infectious Diseases & Immunology, Indian Institute of Chemical Biology, Kolkata, India; Institute 2: Department of Pharmacology, Institute of Postgraduate Medical Education & Research, Kolkata, India).

July 1999 ~ August 2002, Lecturer, Department of Zoology, Midnapore College, Midnapore, India.

Scientific awards:

2020, AAI Abstract Award, The American Association of Immunologists, Immunology 2020TM, Honolulu, HI, USA.

2019, AAI Abstract Award, The American Association of Immunologists, Immunology 2019TM, San Diego, CA, USA.

2018, AAI Abstract Award, The American Association of Immunologists, Immunology 2018TM, Austin, Texas, USA.

2017, AAI Abstract Award, The American Association of Immunologists, Immunology 2017TM, Washington DC, USA.

2016, AAI Abstract Award, The American Association of Immunologists, Immunology 2016TM, Seattle, WA, USA.

2016, 2015 Postdoctoral Achievement Award, (104年度科技部博士後研究人員學術著作獎), Ministry of Science & Technology (MOST), Government of Taiwan.

2005, Upcoming Scientist Award, Indian Pharmacological Society, Kolkata, India.

2005, Gufic Prize, Indian Pharmacological Society, “37th Annual conference of Indian Pharmacological Society”, 2005, Kolkata, India.

Publications: (*=Corresponding author)

  1. Huang C-G, Huang C-T, Dutta A, Chang P-Y, Hsiao M-J, Hsieh Y-C, Shih S-R, Tsao K-C, Yang C-T*. Relative COVID-19 viral persistence and antibody kinetics. medRxiv 2020.07.01.20143917; doi:https://doi.org/10.1101/2020.07.01.20143917
  2. Huang C-T, Hung C-Y, Hseih Y-C, Chang C-S, Velu AB, He Y-C, Huang Y-L, Chen T-A, Chen T-C, Lin C-Y, Lin Y-C, Shih S-R, Dutta A*. 2019. Effect of aloin on viral neuraminidase and hemagglutinin-specific T cell immunity in acute influenza. Phytomedicine, doi.org/10.1016/j.phymed.2019.152904. (2019 IF = 4.268).
  3. Lin Y-C, Hsu C-Y, Huang S-K, Fan Y-H, Huang C-H, Yang C-K, Su W-T, Chang P-C, Dutta A, Liu Y-J, Huang C-T, Chen T-C, Lin C-Y*. 2018. Induction of liver-specific intrahepatic myeloid cells aggregation expands CD8 T cell and inhibits growth of murine hepatoma. OncoImmunology, 7:e1502129. (2019 IF = 5.869).
  4. Huang C-T, Hung C-Y, Chen T-C, Lin C-Y, Lin Y-C, Chang C-S, He Y-C, Huang Y-L, Dutta A*. 2017. Rapamycin adjuvant and exacerbated severe influenza in an experimental mouse model. Scientific Reports, 7:4136. (2019 IF = 3.998).
  5. Dutta A*, Huang CT*. Chen TC, Lin CY, Lin YC, Chang CS, He YC. 2016. Sterilizing immunity to influenza virus infection requires local antigen-specific T cell response in the lungs. Scientific Reports, 6:32973. (2019 IF = 3.998).
  6. Dutta A#, Kang C-W#, Chang L-Y, Mahalingam J, Lin Y-C, Chiang J-M, Hsu C-Y, Huang C-T, Su W-T, Chu Y-Y, Lin C-Y*. 2015. Apoptosis of tumor infiltrating effector TIM-3+CD8+ T cells in colon cancer. Scientific Reports, 5:15659 (#=Equal contribution). (2019 IF = 3.998).
  7. Dutta A, Huang C-T*, Chen T-C, Lin C-Y, Chiu C-H, Lin Y-C, Chang C-S, He Y-C. 2015. IL-10 inhibits neuraminidase activated-TGF-β and facilitates Th1 phenotype during early phase of infection. Nature Communications. 6:6374. (2019 IF = 12.121).
  8. Dutta A, Miaw S-C, Yu JS, Chen T-C, Lin C-Y, Lin Y-C, Chang C-S, He Y-C, Chuang S-H, Yen M-I, Huang C-T*. 2013. Altered T-bet dominance in interferon-g decoupled CD4+ T cells with attenuated cytokine storm and preserved memory in influenza. Journal of Immunology. 190: 4205-4214. (2019 IF = 4.886).
  9. Chang L-Y, Lin Y-C, Mahalingam J, Huang C-T, Chen T-W, Kang C-W, Peng H-M, Chu Y-Y, Chiang J-M, Dutta A, Day Y-J, Chen T-C, Yeh C-T, Lin C-Y*. 2012. Tumor-derived chemokine CCL5 enhances TGF-ss mediated killing of CD8+ T cells in colon cancer by T regulatory cells. Cancer Research. 72:1092-10. (2019 IF = 9.727).
  10. Singh N, Kaur J, Kumar P, Gupta S, Singh N, Ghosal A, Dutta A, Kumar A, Tripathi RP, Siddiqi MI, Mandal C, Dube A*. 2009. An orally effective dihydropyrimidone (DHPM) analogue induces apoptosis like cell death in clinical isolates of Leishmania donovani overexpressing pteridine reductase 1. Parasitology Research. (2019 IF = 1.641).
  11. Lin Y-C, Chang L-Y, Huang C-T, Peng H-M, Dutta A, Chen T-C, Yeh C-T, Lin C-Y*. 2009. Effector/memory but not naïve regulatory T cells are responsible for the loss of concomitant tumor immunity. Journal of Immunology. 182: 6095-104. (2019 IF = 4.886).
  12. Mandal C, Dutta A, Mallick A, Chandra S, Misra L, Sangwan RS, Mandal C*. 2008. Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade. Apoptosis. 13:1450-64. (2019 IF = 4.543).
  13. Dutta A, Sarkar D, Gurib-Fakim A, Mandal C*, Chatterjee M*. 2008. In vivo and in vitro activity of Aloe vera leaf exudate in experimental visceral leishmaniasis. Parasitology Research. 102:1235-1242. (2019 IF = 1.641).
  14. Dutta A, Bandyopadhyay S, Mandal C, Chatterjee* M*. 2007. Aloe vera leaf exudate induces a caspase independent cell death in Leishmania donovani promastigotes. Journal of Medical Microbiology. 56: 629-636. (2019 IF = 2.156).
  15. Dutta A, Ghoshal A, Mandal D, Mondal NB, Banerjee S, Sahu NP, Mandal C*. 2007. Racemoside A, an antileishmanial water soluble natural steroidal saponin, induces programmed cell death in Leishmania donovani. Journal of Medical Microbiology. 56: 1196-1204. (2019 IF = 2.156).
  16. Dutta A, Mandal G, Mandal C*, Chatterjee M*. 2007. In vitro antileishmanial activity of Aloe vera leaf exudate: a potential herbal therapy in leishmaniasis. Glycoconj Journal. 24:81-6. (2019 IF = 2.197).
  17. Sen R, Bandyopadhyay S, Dutta A, Mandal G, Ganguly S, Saha P, Chatterjee M*. 2007. Artemisinin triggers induction of cell cycle arrest and apoptosis in Leishmania donovani promastigotes. Journal of Medical Microbiology. 56: 1213-1218. (2019 IF = 2.156).
  18. Dutta A, Bandyopadhyay S, Mandal C*, Chatterjee M*. 2005. Development of a modified MTT assay for screening antimonial resistant field isolates of Indian visceral leishmaniasis, Parasitology International. 54: 119-22. (2019 IF = 1.866).
  19. Sarkar D, Dutta A, Das M, Sarkar K, Mandal C, Chatterjee M*. 2005. Effect of Aloe vera on nitric oxide production by macrophages during inflammation. Indian Journal of Pharmacology. 37: 371-75. (2019 IF = 0.888).

Conference proceedings: (*=Corresponding author)

  1. Dutta A*, Hung CY, Hseieh YC, Chang CS, Chen TA, Huang YL, Lin YC, Chen TC, Lin CY, Huang CT. 2020. Th1 guided evolution of protective de novo Th17 response in severe influenza. Journal of Immunology. 204: 94.6 (Abstr). (2019 IF = 4.886).
  2. Dutta A*, Hung CY, Hseieh YC, Chang CS, Chen TA, Huang YL, Lin YC, Chen TC, Lin CY, Huang CT. 2020. LAG-3 marks effector to regulatory evolution of Th1 immunity in influenza. Journal of Immunology. 204: 93.3 (Abstr). (2019 IF = 4.886).
  3. Huang W*, Hseieh YC, Hung CY, Chen YY, Chen TC, Chang CS, Huang YL, Chen TA, Lin YC, Lin CY, Huang CT, Dutta A. 2020. Bacterial neuraminidase C reverts neuraminidase A and B mediated suppression of anti-influenza immunity and aggravates the disease in influenza with pneumococcal superinfection. Journal of Immunology. 204: 93.7 (Abstr). (2019 IF = 4.886).
  4. Dutta A*, Huang CT, Hung CY, Chen TC, Lin CY, Lin YC, Chang CS, Chen TA, Huang YL. 2019. Concomitant effector and LAG-3 regulatory responses of Th1 committed cells in acute influenza. Journal of Immunology. 202: 74.4. (Abstr). (2019 IF = 4.886).
  5. Huang CT*, Dutta A, Hung CY, Chen TC, Lin CY, Lin YC, Chang CS, Chen TA, Huang YL. 2019. LAG-3+ induced regulatory T cells confer infectious tolerance with suppression of IFN-g response decoupled from reserved proliferation. Journal of Immunology. 202: 57.16. (Abstr). (2019 IF = 4.886).
  6. Dutta A*, Huang CT, Hseih YC, Chen TC, Lin CY, Lin YC, Chang CS, He YC, Huang YL, Chen TA. 2018. Disease manifestations with immune alteration by bacterial neuraminidases in influenza virus infection with Streptococcus pneumoniae superinfection. Journal of Immunology. 200: 60.5. (Abstr). (2019 IF = 4.886).
  7. Huang CT*, Dutta A, Huang CW, Chen TC, Lin CY, Lin YC, Chang CS, He YC, Huang YL, Chen TA. 2018. Host antigen modulated anti-influenza immunity with antigen level dependent distinct mechanisms of severe influenza. Journal of Immunology. 200: 60.10. (Abstr). (2019 IF = 4.886).
  8. Dutta A*, Huang CT, Chen TC, Lin CY, Lin YC, Chang CS, He YC, Huang YL. 2017. Neuraminidase-mediated TGF-β activation facilitates evolution of protective Th17 immunity. Journal of Immunology. 198:78.22. (Abstr). (2019 IF = 4.886).
  9. Huang CT*, Dutta A, Chen TC, Lin CY, Lin YC, Chang CS, He YC, Huang YL. 2017. Pre-existing matched antigen exacerbates the disease of influenza virus infection by attenuating antigen-specific T cell immunity. Journal of Immunology. 198:203.17.  (Abstr.). (2019 IF = 4.886).
  10. Dutta A*, Huang CT, Chen TC, Lin CY, Lin YC, Chang CS, He YC, Huang YL. 2016. LAG-3 expressing antigen-specific CD4+ T cells attenuate lung inflammation during acute influenza virus infection. Journal of Immunology. 196:148.1 (Abstr). (2019 IF = 4.886).
  11. Huang C-T, Dutta A, Chen TC, Lin CY, Lin YC, Kao KC, Hung CY, Chang CS, He YC, Huang YL. 2016. Rapamycin adjuvant therapy did not improve the outcome of severe influenza virus infection in an experimental mouse model system. Journal of Immunology. 196:76.21 (Abstr). (2019 IF = 4.886).
  12. Dutta A*, Huang CT, Chen TC, Lin CY, Lin YC, Chang CS, He YC, Huang YL. 2016. Sterilizing immunity to influenza virus infection requires local antigen-specific T cell response in the lungs. Journal of Immunology. 196:78.18 (Abstr). (2019 IF = 4.886).
  13. Huang C-T*, Dutta A, Miaw S-C, Drake CG, Powell JD, Pardoll DM. 2015. Infectious tolerance of LAG-3+ regulatory T cells with attenuated T-bet induction. Journal of Immunology. 194:197.15 (Abstr). (2019 IF = 4.886).
  14. Huang C-T, Dutta A, Chen TC, Lin CY, Chiu CH, Lin YC,  Chang CS, He YC. 2015. IL-10 inhibits neuraminidase activated-TGF-β and facilitates Th1 phenotype during early phase of infection. Journal of Immunology. 194:74.6 (Abstr). (2019 IF = 4.886).
  15. Huang CT*, Dutta A, Chen TC, Lin CY, Lin YC, Chang CS, He YC. 2015. Th17 deviation under influence of Th1 response attenuates the inflammation in late phase of influenza virus infection. Journal of Immunology. 194:148.6 (Abstr). (2019 IF = 4.886).
  16. Dutta A*, Drake CG, Powell JD, Pardoll DM, Huang CT. 2014. Reduced T-bet induction in proliferation-interferon-g decoupled CD4+ T cells as a mechanism for propagated T cell tolerance. Journal of Immunology. 192:60.18 (Abstr). (2019 IF = 4.886).
  17. Dutta A*, Chen TC, Lin CY, Chiu CH, Lin YC, Chang CS, He YC, Huang CT. 2014. Viral neuraminidase and the biphasic immune regulation by host cytokine interleukin-10 in influenza. Journal of Immunology. 192:75.19 (Abstr). (2019 IF = 4.886).
  18. Dutta A*, Chen T-C, Lin C-Y, Lin Y-C, Chang C-S, He Y-C, Huang C-T. 2013. Antigen-specific CD4+ T cell derived IL-10 is uniquely pro-inflammatory in the context of acute influenza. Journal of Immunology. 190: 115.13 (Abstr). (2019 IF = 4.886).
  1. Dutta A*, Miaw SC, Yu JS, Chen TC, Lin CY, Lin YC, Chang CS, He YC, Chuang SH, Yen MI, Huang CT. 2013. Altered T-bet dominance in interferon-g decoupled CD4+ T cells with attenuated cytokine storm and preserved memory in influenza. Journal of Immunology. 190: 66.5 (Abstr.). (2019 IF = 4.886).