李國銘助理教授 Dr. Kuo-Ming Lee

Phone: 886-3-2118800 ext.3727

Fax: 886-3-2118700

E-mail: g39002007@mail.cgu.edu.tw

Education

Ph.D. Institute of Molecular Medicine, College of Medicine, National Taiwan University.

M.S., Institute of Microbiology and Immunology, School of Life Science, National Yang-Ming University.

B.S., Department of Life Sciences, National Tsing Hua University.

 

Research experience

Principal Investigator Phase

Aug. 2022-Present:

Assistant Professor, International Master Degree Program for Molecular Medicine in Emerging Viral Infections, Chang Gung University.

Aug. 2021-Jul. 2022:

Assistant Professor, Graduate Program in Molecular Medicine for Master's Degree, Chang Gung University.

Feb. 2021-Jul. 2021:

Assistant Professor, Research Center for Emerging Viral Infections, Chang Gung University.

Aug. 2017-Jan. 2021:

Assistant Research Fellow, Research Center for Emerging Viral Infections, Chang Gung University.

Research interests

  1. Cutting-edge Exploration: Investigating the Molecular Virology of RNA viruses, including enterovirus, influenza virus, and coronavirus to understand the intricacies of their biology and potential therapeutic targets.
  2. Temporal Insight: Utilizing advanced RNA-based methodologies to unravel the spatiotemporal dynamics of RNA virus replication, providing a deeper understanding of viral life cycles.
  3. Pathogen Pioneering: Employing state-of-the-art sequencing techniques for the identification and molecular diagnosis of novel and clinical pathogens, contributing to the advancement of disease detection and control.
  4. RNA Unveiled: Exploring the application of ONT-nanopore sequencing to decipher RNA modifications and unveil secondary structures of RNA viruses, offering key insights into their function and evolution.

Grant and Award:

Grants:

  1. National Science and Technology Council (NSTC 112-2320-B-182-043-MY3), 2023.
  2. National Science and Technology Council (NSTC 109-2320-B-182-045-MY2), 2020.
  3. National Science Council Undergraduate Monographic Study Support (NSC 89-2815-C-001-032R-B), 2000.

Awards:

  1. 2010 First Research Competition (Travel Award for International Conference) of Institute of Biomedical Sciences, Academia Sinica.
  2. 2013 First Research Competition (Travel Award for International Conference) of Institute of Biomedical Sciences, Academia Sinica.
  3. Poster Presentation Award at the 2014 Academia Sinica Mini Symposium on RNA Biology, Academia Sinica.

Publications (Last 5 Years, * corresponding)

  1. Guan-Hong Wu, Kuo-Ming Lee, Chia-Yu Kao, Shin-Ru Shih* (2023, Jun). The internal ribosome entry site determines the neurotropic potential of enterovirus A71. Microbes Infect. 25:105107.
  2. Pei-Lan Shao, Hsiao-Chen Tu, Yu-Nong Gong, Hung-Yu Shu, Ralph Kirby, Li-Yun Hsu, Hui-Yee Yeo, Han-Yueh Kuo, Yi-Chia Huang, Yung-Feng Lin, Hui-Ying Weng, Yueh-Lin Wu, Chien-Chih Chen, Tzen-Wen Chen, Kuo-Ming Lee, Chung-Guei Huang, Shin-Ru Shih, Wei J Chen, Chen-Chi Wu, Chong-Jen Yu*, Shih-Feng Tsai* (2023, Apr). Emergence and Persistent Dominance of SARS-CoV-2 Omicron BA.2.3.7 Variant, Taiwan. Emerg Infect Dis. 29:792-796.
  3. Yi-Ju Han, Kuo-Ming Lee, Guan-Hong Wu, Yu-Nong Gong, Avijit Dutta, Shin-Ru Shih* (2023 Feb). Targeting influenza A virus by splicing inhibitor herboxidiene reveals the importance of subtype-specific signatures around splice sites. J Biomed Sci. 30:10.
  4. Kuo-Ming Lee, Syh-Jae Lin, Chung-Jung Wu, Rei-Lin Kuo* (2023 Feb). Race with virus evolution: The development and application of mRNA vaccines against SARS-CoV-2. Biomed J. 46:70-80.
  5. Yu-An Kung#, Kuo-Ming Lee#, Huan-Jung Chiang#, Sheng-Yu Huang, Chung-Jung Wu, Shin-Ru Shih* (2022, Jun). Molecular Virology of SARS-CoV-2 and Related Coronaviruses. Microbiol Mol Biol Rev, 86(2):e0002621. # equal contribution.
  6. Yu-Nong Gong, Kuo-Ming Lee, Shin-Ru Shih* (2022). Evolution and Epidemiology of SARS-CoV-2 Virus. Methods Mol Biol, 2452:3-18.
  7. Richard Janissen, Andrew Woodman, Djoshkun Shengjuler, Thomas Vallet, Kuo-Ming Lee, Louis Kuijpers, Ibrahim M Moustafa, Fiona Fitzgerald, Peng-Nien Huang, Angela L Perkins, Daniel A Harki, Jamie J Arnold, Belén Solano, Shin-Ru Shih, Marco Vignuzzi, Craig E Cameron, Nynke H Dekker (2021, Nov). Induced intra- and intermolecular template switching as a therapeutic mechanism against RNA viruses. Mol Cell, 81(21), 4467-4480.
  8. Sheng-Yu Huang, Yu-An Kung, Peng-Nien Huang, Sheng-Yun Chang, Yu-Nong Gong, Yi-Ju Han, Huan-Jung Chiang, Kuan-Ting Liu, Kuo-Ming Lee, Chia-Yu Chang, Chia-Ching Chang, Chung-Guei Huang, Shin-Ru Shih* (2021 Mar). Stability of SARS-CoV-2 Spike G614 Variant Surpasses That of the D614 Variant after Cold Storage. mSphere, 6(2), e00104-21.
  9. Yu-Nong Gong, Kuo-Chien Tsao, Mei-Jen Hsiao, Chung-Guei Huang, Peng-Nien Huang, Po-Wei Huang, Kuo-Ming Lee, Yi-Chun Liu, Shu-Li Yang, Rei-Lin Kuo, Kuan-Fu Chen, Yen-Chin Liu, Sheng-Yu Huang, Hsing-I Huang, Ming-Tsan Liu, Ji-Rong Yang, Cheng-Hsun Chiu, Cheng-Ta Yang, Guang-Wu Chen, Shin-Ru Shih* (2020 Dec). SARS-CoV-2 genomic surveillance in Taiwan revealed novel ORF8-deletion mutant and clade possibly associated with infections in Middle East. Emerging Microbes & Infections, 9(1), 1457-1466.
  10. Chung-Guei Huang#, Kuo-Ming Lee#, Mei-Jen Hsiao, Shu-Li Yang, Peng-Nien Huang, Yu-Nong Gong, Tzu-Hsuan Hsieh, Po-Wei Huang, Ya-Jhu Lin, Yi-Chun Liu, Kuo-Chien Tsao, Shin-Ru Shih* (2020, Jul). Culture-Based Virus Isolation To Evaluate Potential Infectivity of Clinical Specimens Tested for COVID-19. Journal of Clinical Microbiology, 58(8), e01068-20). # equal contribution.
  11. Bo-Shiun Chen, Hou-Chen Lee, Kuo-Ming Lee, Yu-Nong Gong and Shin-Ru Shih* (2020, Feb). Enterovirus and Encephalitis. Frontiers in Microbiology, 11, 261.
  12. Kuo-Ming Lee, Chih-Ching Wu, Shang-En Wu, Ya-Han Lin, Li-Ting Wang, Chun-Ru Chang, Peng-Nien Huang, Shin-Ru Shih, Rei-Lin Kuo* (2020, Apr). The RNA-dependent RNA polymerase of enterovirus A71 associates with ribosomal proteins and positively regulates protein translation. RNA Biology, 17(4), 608-622.
  13. Kuo-Ming Lee, Yu-Nong Gong, Shin-Ru Shih* (2020, Nov). Methods for detection and study of virus-derived small RNAs produced from the intramolecular base-pairing region of the picornavirus genome. Methods, 183,4-12.
  14. Tzu-Wei Chuang, Chia-Chen Lu, Chun-Hao Su, Pei-Yu Wu, Sarasvathi Easwvaran, Chi-Chieh Lee, Hung-Che Kuo, Kuan-Yang Hung, Kuo-Ming Lee, Ching-Yen Tsai, Woan-Yuh Tarn* (2019, Mar). The RNA Processing Factor Y14 Participates in DNA Damage Response and Repair. iScience, 13, 402-415 (SCIE: 4.447, 15/71, Multidisciplinary Sciences)
  15. Andrew Woodman, Kuo-Ming Lee, Richard Janissen, Yu-Nong Gong, Nynke H. Dekker, Shin-Ru Shih, Craig E. Cameron* (2019, Feb). Predicting Intraserotypic Recombination in Enterovirus 71. Journal of Virology, 93(4), e02057-18.
  16. Kuo-Ming Lee, Yu-Nong Gong, Tzu-Hsuan Hsieh, Andrew Woodman, Nynke H. Dekker, Craig E. Cameron, Shin-Ru Shih* (2018, Jun). Discovery of Enterovirus A71-like nonstructural genomes in recent circulating viruses of the Enterovirus A species. Emerging Microbes & Infections, 7(1),111.
  17. Kuo-Ming Lee, Chi-Jene Chen, and Shin-Ru Shih* (2017, Jul). Regulation Mechanisms of Viral IRES-Driven Translation. Trends in Microbiology, 25(7), 546-561.

Database (* corresponding)

Lee, K.-M., Tarn, W.-Y.* (2012) THRAP3/TRAP150 in Atlas of Genetics and Cytogenetics in Oncology and Haematology (a structured review; http://atlasgeneticsoncology.org/Genes/THRAP3ID42960ch1p34.html).