Your browser does not support JavaScript!
洪錦堂教授 Dr. Jim-Tong Horng

Current Position: Professor, Department of Biochemistry and Molecular Biology, Chang Gung University, Taiwan
Education :英國劍橋大學生化學博士
Specialties:Membrane trafficking and virology
TEL:(03)211-8800 ext. 5156
Mail:jimtong@mail.cgu.edu.tw
Homepage:
http://memo.cgu.edu.tw/jim-tong/index.htm

Research theme:

Dr. Horng’s research focuses mainly on the molecular interactions between RNA viruses and host cells, and on the development of compounds active against influenza virus and enterovirus 71. There is a special emphasis on the regulation of cellular response to viral replication. These studies will elucidate the molecular basis of viral replication.

 

Research Details:

*Development and molecular study antiviral drugs against influenza virus and enterovirus 71 and their efficacy in animal models.

*Molecular mechanism of endoplasmic reticulum response induced and modulated by enterovirus 71

*Communal host factors required for (+) RNA virus replication, including enterovirus 71 and hepatitis C virus.

*Regulation of enterovirus 71 replication by cellular microRNA and its target identification by proteomic approach.

*Development and molecular study of antiviral drugs against influenza virus  
 

Recent publications (* corresponding author, 2004-2010)

1.Shin-Ru Shih, Tzu-Yun Chu, Gadarla Randheer Reddy, Sung-Nain Tseng, Hsiun-Ling Chen, Jiann-Yih Yeh, Yu-Sheng Chao, John T.-A. Hsu, Hsing-Pang Hsieh, and Jim-Tong Horng* (2010), Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity, Journal of Biomedical Science (in press) (SCI 2.013, Ranking 54%)

2.Jia-Rong Jheng, Kean Seng Lau, Wen-Fang Tang, Ming-Hsien Wu, and Jim-Tong Horng*(2010), Endoplasmic reticulum stress is induced and modulated by enterovirus 71, Cellular Microbiology 12(6):796-813 (SCI 5.598, Ranking 13.18%))

3.Jiann-Yih Yeh†, Mohane Selvaraj Coumar†, Jim-Tong Horng†, Hui-Yi Shiao, Fu-Ming Kuo, Hui-Ling Lee, In-Chun Chen, Chun-Wei Chang, Wen-Fang Tang, Sung-Nain Tseng, Chi-Jene Chen, Shin-Ru Shih, John T.-A. Hsu, Chun-Chen Liao, Yu-Sheng Chao and Hsing-Pang Hsieh (2010), Anti-influenza drug discovery: Structure-activity relationship and mechanistic insight into novel angelicin derivatives. Journal of Medicinal Chemistry, 53(4):1519-33 (†equal contribution) (SCI4.898, Medicinal Chemistry 3/41=7.3%)

4.Shin-Ru Shih*†, Jim-Tong Horng†, Leo L. M. Poon, Tzu-Chun Chen, Jiann-Yih Yeh, Hsing-Pang Hsieh, Sung-Nain Tseng, Chiayn Chiang, Wan-Ling Li, Yu-Sheng Chao, and John T.-A. Hsu (2010), BPR2-D2 targeting viral ribonucleoprotein complex-associated function inhibits oseltamivir-resistant influenza viruses, Journal of Antimicrobial Chemotherapy 65:63-71(†equal contribution) (SCI4.328, Infectious diseases 8/51=15.6%)

5.Tzou-Yien Lin†, Yi-Chun Liu†, Jia-Rong Jheng, Hui-Ping Tsai, Jia-Tsrong Jan, Wen-Rou Wong and Jim-Tong Horng* (2009) Anti-enterovirus 71 Activity Screening of Chinese Herbs with Anti-infection and Inflammation Activities, American Journal of Chinese Medicine, 37:143–158 (SCI1.058, General and internal medicine 68/107=63.5%)

6.Jing-Yi Lin, Mei-Ling Li, Peng-Nien Huang, Kun-Yi Chien, Jim-Tong Horng and Shin-Ru Shih (2008) Heterogeneous nuclear ribonuclear protein K interacts with the enterovirus 71 5’-untranslated region and participates in virus replication, Journal of General Virology, 89:2540-2549

7.Ying-Ju Chen, Shih-Jhan Zeng, John TA Hsu, Jim-Tong Horng, Hong-Ming Yang, Shin-Ru Shih, Yu-Ting Chu, Tzong-Yuan Wu (2008) Amantadine as a regulator of internal ribosome entry site, Acta Pharmacol Sin. 29:1327-33.

8.Wen-Fang Tang, Shing-Ying Yang, Bin-Wen Wu, Jia-Rong Jheng, Yin-Li Chen, Chung-Hsuan Shih, Kwang-Huei Lin, Hsin-Chi Lai, Petrus Tang and Jim-Tong Horng*(2007)  Reticulon 3 binds to 2C protein of enterovirus 71 and is required for viral replication, Journal of  Biological Chemistry, 282:5888-5898 (SCI 5.520, Ranking 40/263=14.9%)

9.Bin-Wen Wu, Tai-Long Pan, Yann-Lii Leu, Yu-Kaung Chang, Pei-Ju Tai, Kwang-Huei Lin, Jim-Tong Horng* (2007) Antiviral effects of Salvia miltiorrhiza (Danshen) against enterovirus 71, American Journal of Chinese Medicine, 35:153-168 (SCI1.058, General and internal medicine 68/107=63.5%)

10.Tung WH, Sun CC, Hsieh HL, Wang SW, Horng JT, Yang CM. (2007) EV71 induces VCAM-1 expression via PDGF receptor, PI3-K/Akt, p38 MAPK, JNK and NF-kappaB in vascular smooth muscle cells. Cell Signal. 19(10):2127-37 (SCI4.147, Ranking 49/156=31.4%)

11.Jun-Rong Wei, Yu-Huan Tsai, Yu-Tze Horng, Po-Chi Soo, Shang-Chen Hsieh, Po-Ren Hsueh, Jim-Tong Horng, Paul Williams, Hsin-Chih Lai (2006) A mobile quorum-sensing system in Serratia marcescens. Journal of Bacteriology, 188(4):1518-25  (SCI 4.013, Ranking 17/94=18%)

12.Yu-Kaung Chang, Jim-Tong Horng, Ren-Ze Huang, Shiuan-Yaw Lin (2006) Direct recovery of clotting factor IX from unclarified human plasma by expanded bed ion exchange chromatography, Biochemical Engineering Journal, 30:138-146(SCI 1.899, CHEMICAL ENGINEERING 23/116=19.8%)

13.Yu-Kaung Chang, Jim-Tong Horng, Ren-Ze Huang, Shiuan-Yaw Lin (2006) Direct capture of factor IX from unclarified human plasma by IMEBAC.  Biochemical Engineering Journal, 29:12-22 (SCI 1.899, CHEMICAL ENGINEERING 23/116=19.8%)

14.Wen-Rou Wong, Yu-Yun Chen, Shun-Min Yang, Yin-Li Chen, and Jim-Tong Horng* (2005) Phosphorylation of PI3K/Akt and MAPK/ERK in an early entry step of enterovirus 71, Life Sciences, 78: 82-90 (SCI 2.583, Ranking 39.7%)

15.Horng, Jim-Tong* and Tan, C.-Y. (2004) Biochemical characterization of the coating mechanism of the endosomal donor compartment of synaptic vesicles.  Neurochemical Research 29:1411-16 (SCI 1.811, Ranking 162/275=58.9%)

Past publication

1.Faundez, V. Horng, J-T, and Kelly, R.B. (1998) A function for the AP-3 coat complex in synaptic vesicle formation from endosomes. Cell, 93:423-432 (First two authors contributed equally to this paper)

2.Pool, M., Lopez-Huertas, E., Horng, J.-T. and Baker, A. (1998) NADPH is a specific inhibitor of protein import into glyoxysomes. Plant Journal, 15:101-114

3.Clift-O'Grady, L., Desnos, C., Lichtenstein, Y., Faundez, V., Horng, J.-T. and Kelly, R.B. (1998) A method for the reconstitution of synaptic vesicle biogenesis from PC12 membranes. Methods, a companion to methods in Enzymology, 16:150-159

4.Salem , N., Faundez, V., Horng, J.-T., and Kelly, R.B. (1998) A v-SNARE participates in synaptic vesicle formation mediated by the AP3 adaptor complex. Nature Neuroscience, 1:551-556

5.Faundez, V., Horng, J.-T. and Kelly, R.B. (1997) ARF1 is required for synaptic vesicle budding in PC12 cells. J. Cell Biology, 138:505-515

6 Horng, J.-T., Behari, R., Burke, L.E.C.-A. and Baker, A. (1995) Import of glycolate oxidase: Investigation of the energy requirement and targeting signal. Eur. J. Biochem. 230:157-163

Presentations

1.The XIIIth International Congress of Virology, International Union of Microbiological Societies 2005,San Francisco, USA (Selected Speaker), 2005: Enterovirus 71 replication complex is associated with cellular membranes

2.Chang Gung University, 2005: Reticulon 3 binds to 2C protein of enterovirus 71 and is required for viral replication

3.National Central University, 2006: Molecular studies of host-enterovirus 71 interaction

4.American Society for Virology 28th Annual Meeting, 2009: Enterovirus 71 induces endoplasmic reticulum stress and modulates the unfolded protein response signaling cascade to benefit viral infection (delivered by Jia-Rong Jeng)

5.National Central University, 2009, Drug discovery against influenza viruses.

6.National Chung Cheng University, 2009, War against influenza viruses

Patent

1. 林世明,李世光,李世元,朱淑芳,蕭文欣,陳志傑,王安邦,高全良,林啟萬,蘇慶琅,董育蕙,張光男,黃榮山,張培仁,吳文中,陳家智,徐明璋,許世明,洪錦堂,“一種破壞病毒致病性之化學原料”, ROC Patent Document No. 200423926 (November 16, 2004).

2 . 林世明,李世光,李世元,朱淑芳,蕭文欣,陳志傑,王安邦,高全良,林啓萬,蘇慶琅,董育蕙,張光男,黃榮山,張培仁,吳文中,陳家智,徐明璋,許世明,洪錦堂,“一種破壞冠狀病毒致病性之活性劑”, ROC Patent No. I304338 (December 21, 2008).

3. Hsieh, Hsing-Pang; Hsu, Tsu-An; Yeh, Jiann-Yih; Horng, Jim-Tong; Shih, Shin-Ru; Chang, Sui-yuan; Chao, Yu-Sheng "COUMARIN COMPOUNDS AND THEIR USE FOR TREATING      VIRAL INFECTION" US Patent Application No.US2009000481789 (December 17, 2009)

Expert Reviewer

BMC Bioinformatics (2005)

Cell Death and Differentiation (2006)

Apoptosis (2007)

Evidence based complementary and alternative medicine (2008)

Microscopy Research and Technique (2008)

 

瀏覽數