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翁國峰助理研究員 Dr. Kuo-Feng Weng
Kuo-Feng Weng
Assistant Research Fellow
Research Center for Emerging Viral Infections, Chang Gung University
259, Wen-Hwa 1st Road, Kwei-Shan, Taoyuan, Taiwan, 333, R.O.C.
Phone:  886-3-2118800 ext. 3723
Fax:  886-3-2118174
 

Education/Training
2011-2013      Chang Gung University, Tao-Yuan, Taiwan
                    Postdoctoral, The Center for Molecular and Clinical Immunology
2009-2011      Chang Gung University, Tao-Yuan, Taiwan
                       Research Center for Emerging Viral Infections
2004-2009     Chang Gung University, Tao-Yuan, Taiwan
                   Ph.D., Graduate Institute of Biomedical Sciences
2002-2004     Chang Gung University, Tao-Yuan, Taiwan
                   M.S., Graduate Institute of Medical Biotechnology
1998-2002     Chang Gung University, Tao-Yuan, Taiwan
                   B.Sc., School of Medical Technology

Research fields and techniques
Virology
Molecular and cellular biology
Proteomic approaches
Antiviral development
Animal study (mice)

 

Grants

起迄年月

研究計畫名稱

主持人

補助單位

2015/04/01~2016/07/31

腸病毒聚合酶進入細胞核的能力對病毒感染及致病力的重要性

翁國峰

科技部計畫 MOST 104-2320-B-182-004-

 

科技部大專生專題計畫指導教授

起迄年月

研究計畫名稱

學生姓名

計畫編號

2015/07/01~2016/02/28

奈米顆粒抑制腸病毒71型感染的機制

梁潔瑜

104-2815-C-182-006-B

2015/07/01~2016/02/28

腸病毒713D聚合NLS序列對病毒感染的影響機制

謝明妃

104-2815-C-182-003-B

 

Publications

1.  Shih, S.R., Tsai, M.C., Tseng, S.N., Won, K.F., Shia, K.S., Li, W.T., Chern, J.H., Chen, G.W., Lee, C.C., Lee, Y.C., Peng, K.C., and Chao, Y.S., Mutation in enterovirus 71 capsid protein VP1 confers resistance to the inhibitory effects of pyridyl imidazolidinone. Antimicrob Agents Chemother, 2004. 48(9): p. 3523-9.

2.  Chen, T.C., Weng, K.F., Chang, S.C., Lin, J.Y., Huang, P.N., and Shih, S.R., Development of antiviral agents for enteroviruses. J Antimicrob Chemother, 2008. 62(6): p. 1169-73.

3.   Shih, S.R., Weng, K.F., Stollar, V., and Li, M.L., Viral protein synthesis is required for Enterovirus 71 to induce apoptosis in human glioblastoma cells. J Neurovirol, 2008. 14(1): p. 53-61.

4.   Lin, J.Y., Chen, T.C., Weng, K.F., Chang, S.C., Chen, L.L., and Shih, S.R., Viral and host proteins involved in picornavirus life cycle. J Biomed Sci, 2009. 16: p. 103.

5.  Weng, K.F., Li, M.L., Hung, C.T., and Shih, S.R., Enterovirus 71 3C protease cleaves a novel target CstF-64 and inhibits cellular polyadenylation. PLoS Pathog, 2009. 5(9): p. e1000593.

6.  Weng, K.F., Chen, L.L., Huang, P.N., and Shih, S.R., Neural pathogenesis of enterovirus 71 infection. Microbes Infect, 2010. 12(7): p. 505-10.

7.  Chen, S.C., Chang, L.Y., Wang, Y.W., Chen, Y.C., Weng, K.F., Shih, S.R., and Shih, H.M., Sumoylation-promoted enterovirus 71 3C degradation correlates with a reduction in viral replication and cell apoptosis. J Biol Chem, 2011. 286(36): p. 31373-84.

8.  Huang, H.I., Weng, K.F., and Shih, S.R., Viral and host factors that contribute to pathogenicity of enterovirus 71. Future Microbiol, 2012. 7(4): p. 467-79.

9.  Chen, L.L., Kung, Y.A., Weng, K.F., Lin, J.Y., Horng, J.T., and Shih, S.R., Enterovirus 71 infection cleaves a negative regulator for viral internal ribosomal entry site-driven translation. J Virol, 2013. 87(7): p. 3828-38.

10. Huang, H.I., Lin, J.Y., Chen, H.H., Yeh, S.B., Kuo, R.L., Weng, K.F., and Shih, S.R., Enterovirus 71 infects brain-derived neural progenitor cells. Virology, 2014. 468-470: p. 592-600.

11. Velu, A.B., Chen, G.W., Hsieh, P.T., Horng, J.T., Hsu, J.T., Hsieh, H.P., Chen, T.C., Weng, K.F., and Shih, S.R., BPR-3P0128 inhibits RNA-dependent RNA polymerase elongation and VPg uridylylation activities of Enterovirus 71. Antiviral Res, 2014. 112: p. 18-25.

12.  Weng, K.F., Hung, C.T., Hsieh, P.T., Li, M.L., Chen, G.W., Kung, Y.A., Huang, P.N., Kuo, R.L., Chen, L.L., Lin, J.Y., Wang, R.Y., Chen, S.J., Tang, P., Horng, J.T., Huang, H.I., Wang, J.R., Ojcius, D.M., Brewer, G., and Shih, S.R., A cytoplasmic RNA virus generates functional viral small RNAs and regulates viral IRES activity in mammalian cells. Nucleic Acids Res, 2014. 42(20): p. 12789-805.

13.  Weng, K.F., Hsieh, P.T., Huang, H.I., and Shih, S.R., Mammalian RNA virus-derived small RNA: biogenesis and functional activity. Microbes Infect, 2015. 17(8): p. 557-63. 

 

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