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翁國峰助理研究員 Dr. Kuo-Feng Weng
Kuo-Feng Weng
Assistant Research Fellow
Research Center for Emerging Viral Infections, Chang Gung University
259, Wen-Hwa 1st Road, Kwei-Shan, Taoyuan, Taiwan, 333, R.O.C.
Phone:  886-3-2118800 ext. 3723
Fax:  886-3-2118174

2011-2013      Chang Gung University, Tao-Yuan, Taiwan
                    Postdoctoral, The Center for Molecular and Clinical Immunology
2009-2011      Chang Gung University, Tao-Yuan, Taiwan
                       Research Center for Emerging Viral Infections
2004-2009     Chang Gung University, Tao-Yuan, Taiwan
                   Ph.D., Graduate Institute of Biomedical Sciences
2002-2004     Chang Gung University, Tao-Yuan, Taiwan
                   M.S., Graduate Institute of Medical Biotechnology
1998-2002     Chang Gung University, Tao-Yuan, Taiwan
                   B.Sc., School of Medical Technology

Research fields and techniques
Molecular and cellular biology
Proteomic approaches
Antiviral development
Animal study (mice)










科技部計畫 MOST 104-2320-B-182-004-

















1.  Shih, S.R., Tsai, M.C., Tseng, S.N., Won, K.F., Shia, K.S., Li, W.T., Chern, J.H., Chen, G.W., Lee, C.C., Lee, Y.C., Peng, K.C., and Chao, Y.S., Mutation in enterovirus 71 capsid protein VP1 confers resistance to the inhibitory effects of pyridyl imidazolidinone. Antimicrob Agents Chemother, 2004. 48(9): p. 3523-9.

2.  Chen, T.C., Weng, K.F., Chang, S.C., Lin, J.Y., Huang, P.N., and Shih, S.R., Development of antiviral agents for enteroviruses. J Antimicrob Chemother, 2008. 62(6): p. 1169-73.

3.   Shih, S.R., Weng, K.F., Stollar, V., and Li, M.L., Viral protein synthesis is required for Enterovirus 71 to induce apoptosis in human glioblastoma cells. J Neurovirol, 2008. 14(1): p. 53-61.

4.   Lin, J.Y., Chen, T.C., Weng, K.F., Chang, S.C., Chen, L.L., and Shih, S.R., Viral and host proteins involved in picornavirus life cycle. J Biomed Sci, 2009. 16: p. 103.

5.  Weng, K.F., Li, M.L., Hung, C.T., and Shih, S.R., Enterovirus 71 3C protease cleaves a novel target CstF-64 and inhibits cellular polyadenylation. PLoS Pathog, 2009. 5(9): p. e1000593.

6.  Weng, K.F., Chen, L.L., Huang, P.N., and Shih, S.R., Neural pathogenesis of enterovirus 71 infection. Microbes Infect, 2010. 12(7): p. 505-10.

7.  Chen, S.C., Chang, L.Y., Wang, Y.W., Chen, Y.C., Weng, K.F., Shih, S.R., and Shih, H.M., Sumoylation-promoted enterovirus 71 3C degradation correlates with a reduction in viral replication and cell apoptosis. J Biol Chem, 2011. 286(36): p. 31373-84.

8.  Huang, H.I., Weng, K.F., and Shih, S.R., Viral and host factors that contribute to pathogenicity of enterovirus 71. Future Microbiol, 2012. 7(4): p. 467-79.

9.  Chen, L.L., Kung, Y.A., Weng, K.F., Lin, J.Y., Horng, J.T., and Shih, S.R., Enterovirus 71 infection cleaves a negative regulator for viral internal ribosomal entry site-driven translation. J Virol, 2013. 87(7): p. 3828-38.

10. Huang, H.I., Lin, J.Y., Chen, H.H., Yeh, S.B., Kuo, R.L., Weng, K.F., and Shih, S.R., Enterovirus 71 infects brain-derived neural progenitor cells. Virology, 2014. 468-470: p. 592-600.

11. Velu, A.B., Chen, G.W., Hsieh, P.T., Horng, J.T., Hsu, J.T., Hsieh, H.P., Chen, T.C., Weng, K.F., and Shih, S.R., BPR-3P0128 inhibits RNA-dependent RNA polymerase elongation and VPg uridylylation activities of Enterovirus 71. Antiviral Res, 2014. 112: p. 18-25.

12.  Weng, K.F., Hung, C.T., Hsieh, P.T., Li, M.L., Chen, G.W., Kung, Y.A., Huang, P.N., Kuo, R.L., Chen, L.L., Lin, J.Y., Wang, R.Y., Chen, S.J., Tang, P., Horng, J.T., Huang, H.I., Wang, J.R., Ojcius, D.M., Brewer, G., and Shih, S.R., A cytoplasmic RNA virus generates functional viral small RNAs and regulates viral IRES activity in mammalian cells. Nucleic Acids Res, 2014. 42(20): p. 12789-805.

13.  Weng, K.F., Hsieh, P.T., Huang, H.I., and Shih, S.R., Mammalian RNA virus-derived small RNA: biogenesis and functional activity. Microbes Infect, 2015. 17(8): p. 557-63. 


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