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林素珍助理教授 Dr. Sue-Jane Lin

Current Position: Assistant Professor, Department of Medical Biotechnology and Labroatory Sciences, Chang Gung University, Taiwan
Education :Institute of Microbiology and Immunology, National Yang-Ming University, Taiwan
Specialties:Viral Immunology
TEL :886-3-2118800 ext. 3727
Mail:suejane.lin@mail.cgu.edu.tw 

Homepage:http://163.25.101.149/sjlin/index.html

Despite many advances in biomedical studies, viral infections, whether related to virus induced-immunopathogenesis or -tumorgenesis remain a major threat to human health. In the past decades, Dr. Lin’s lab has studied the emergence of acute or persistent viral infections in Taiwan caused by hepatitis B virus, hepatitis C virus, Epstein-Barr virus, enterovirus, dengue virus, SARS coronavirus, human immunodeficiency virus, human T cell leukemia virus and papillomavirus as well as re-emerging viruses, such as influenza virus. Dr. Lin’s lab focuses especially on the studies of viral immunology. Specific goals are listed as following: (1) the roles of microRNA in persistent LCMV cl-13 infection. (2) the effects of Epstein-Barr virus on human B cell immortalization. (3) the anti-viral immune responses to influenza virus and enterovirus infections. Her group has successfully established mouse models for influenza virus and LCMV, and for EBV infection in primary human B cells. Both immunology and virology experiments may advance to elucidate anti-viral immune responses and collateral immunopathologic effects. Their studies will also be helpful for the development of therapeutic drugs, preventive vaccines and immunotherapy protocols for acute and persistent viral infection. 

Publications:
 

  1. Ya-Ching Chou, Chi-Long Chen, Te-Huei Yeh, Sue-Jane Lin, Mei-Ru Chen, Shin-Lian Doong, Jean Lu and Ching-Hwa Tsai. 2012. Involvement of Recepteur d'Origine Nantais Receptor Tyrosine Kinase in Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma and its Metastasis.The American Journal of Pathology. (In Press)
  2. Huey-Huey Chua*, Hsin-Yi Chiu*, Sue-Jane Lin*, Pei-Lun Weng, Jiun-Han Lin, Shao-Wen Wu, Shu-Chun Tsai and Ching-Hwa Tsai. 2012. p53 and Sp1 cooperate to regulate the expression of Epstein–Barr viral Zta protein. Journal of Medical Virology. 84: 1279-1288. *Equal contribution
  3. Erh-Fang Hsieh*, Sue-Jane Lin*, Chee-Keng Mok*, Guang-Wu Chen, Chih-Heng Huang, Yeau-Ching Wang, Tzu-Chun Chen, Chi-Jene Chen, David M Ojcius and Shin-Ru Shih. 2011. Altered pathogenicity for seasonal influenza virus by single reassortment of the RNP genes derived from the 2009 pandemic influenza virus. The Journal of Infectious Diseases. 204: 864-872.*Equal contribution
  4. Ya-Ching Chou, Sue-Jane Lin, Jean Lu, Te-Huei Yeh, Chi-Long Chen, Pei-Lun Weng, Jiun-Han Lin, Ming Yao and Ching-Hwa Tsai. 2011. Requirement for LMP1-induced RON receptor tyrosine kinase in Epstein-Barr virus-mediated B-cell proliferation. Blood. 118: 1340-1349.
  5. Chun-Chung Lee, Ko-Jiunn Liu, Yu-Chen Wu, Sue-Jane Lin, Ching-Chun Chang and Tze-Sing Huang. 2011. Sesamin inhibits macrophage-induced vascular endothelial growth factor and matrix metalloproteinase-9 expression and proangiogenic activity in breast cancer cells. Inflammation. 34: 209-221. 
  6. Pei-Fang Tsai, Sue-Jane Lin, Pei-Lun Weng, Shu-Chun Tsai, Jiun-Han Lin, Ya-Ching Chou and Ching-Hwa Tsai. 2010. Interplay between PKCδ and Sp1 on Histone DeacetylaseInhibitor-Mediated Epstein-Barr Virus Reactivation. Journal of Virology. 85: 2373-2385.
  7. Siwei Nie, Sue-Jane Lin, Sung-kwon Kim, Raymond M. Welsh and Liisa K. Selin. 2010. Pathological Features of Heterologous Immunity Are Regulated by the Private Specificities of the Immune Repertoire. The American Journal of Pathology. 176: 2107-2112.
  8. Po-Wen Chen, Sue-Jane Lin, Shu-Chun Tsai, Jiun-Han Lin, Mei-Ru Chen, Jiin-Tarng Wang, Chung-Pei Lee and Ching-Hwa Tsai. 2010. Regulation of microtubule dynamics through phosphorylation on stathmin by Epstein-Barr virus kinase BGLF4. The Journal of Biological Chemistry. 285: 10053-10063.
  9. Yoon-Joong Kang, Xiaosong Wang, Sue-Jane Lin, Yen-Ming Hsu and Hsiu-Ching Chang. 2010. An active CD8α/pMHCI interaction is required for CD8 single positive thymocyte differentiation. European Journal of Immunology. 40:836-848.
  10. Shu-Chun Tsai, Sue-Jane Lin, Po-Wen Chen, Wen-Yi Luo, Te-Huei Yeh, Hsei-Wei Wang, Chi-Ju Chen and Ching-Hwa Tsai. 2009. EBV Zta protein induces the expression of interleukin-13, promoting the proliferation of EBV-infected B cells and lymphoblastoid cell lines. Blood. 114:109-118.
  11. Heng-Huan Lee, Shih-Shin Chang, Sue-Jane Lin, Huey-Huey Chua, Tze-Jiun Tsai, Kevin Tsai, You-Chang Lo, Hong-Chen Chen and Ching-Hwa Tsai. 2008. Essential role of PKCδ in histone deacetylase inhibitor-induced Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells. Journal of General Virology. 89: 878-883.
  12. Sue-Jane Lin, Alex T Chen and Raymond M Welsh. 2008. Immune system derived from homeostatic proliferation generates normal CD8 T-cell memory but altered repertoires and diminished heterologous immune responses. Blood. 112: 680-689.
  13. Sue-Jane Lin, Chungming Chang, Ah-Kau Ng, Shu-Han Wang, Jia-Je Li and Cheng-po Hu. 2007. Prevention of TGF-β-induced apoptosis by interlukin-4 through Akt activation and p70S6K survival signaling pathways. Apoptosis. 12: 1659-1670.
  14. Sue-Jane Lin, Craig D. Peacock, Kapil Bahl and Raymond M. Welsh. 2007. Programmed death-1 (PD-1) defines a transient and dysfunctional oligoclonal T cell population in acute homeostatic proliferatio. The Journal of Experimental Medicine. 204: 2321-2333.
  15. Sue-Jane Lin, Pei-Yun Shu, Chungming Chang, Ah-Kau Ng and Cheng-po Hu. 2003. IL-4 suppresses the expression and the replication of hepatitis B virus in the hepatocellular carcinoma cell line Hep3B. The Journal of Immunology. 171: 4708-4716.
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